Keywords: catalysis, photochemistry, protein dynamics, electrochemistry, vibrational energy transfer, ultrafast infrared spectroscopy.
Resolving structure and dynamics of short lived molecular species is the key to molecular function and reaction mechanisms. To access these structures, a method combining structure resolution and high time resolution is required. Ultrafast two-dimensional infrared (2D-IR) spectroscopy is an excellent complement to commonly used methods such as NMR spectroscopy in the presence of fast chemical exchange and for investigating short lived species. Different types of 2D-IR experiments have been implemented that measure energy transfer,1 couplings2,3 and correlations4 of vibrations, which reveal molecular structure and its change in time.
The use of mixed IR/VIS techniques further extends the application range of 2D-IR spectroscopy,5 enabling studies of ultrafast light triggered processes,4 subensemble-selective photochemistry6 as well as surface specific,7 highly sensitive experiments.
In my talk I will illustrate the utility of different types of 2D-IR experiments, using examples from enantioselective catalysis, photochemistry, electrochemistry and protein biophysics.
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2 A. T. Messmer, K. M. Lippert, S. Steinwand, E.-B. W. Lerch, K. Hof, D. Ley, D. Gerbig, H. Hausmann, P. R. Schreiner and J. Bredenbeck, Chem. Eur. J., 2012, 18, 14989–14995.
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4 J. Bredenbeck, J. Helbing, K. Nienhaus, G. U. Nienhaus and P. Hamm, Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 14243–14248.
5 L. J. G. W. van Wilderen and J. Bredenbeck, Angew. Chem. Int. Ed., 2015, 54, 11624–11640.
6 L. J. G. W. van Wilderen, A. T. Messmer and J. Bredenbeck, Angew. Chem. Int. Ed., 2014, 53, 2667–2672.
7 J. Bredenbeck, A. Ghosh, H.-K. Nienhuys and M. Bonn, Acc. Chem. Res., 2009, 42, 1332–1342.
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