Elucidation of the chemical and biological roles of five carbon metabolism in diverse biological systems

Five-carbon metabolism derives from the central hub of the isoprenoid pathway, which is necessary for an array of critical bioactivities, including cell membrane integrity (e.g., cholesterol), glycoprotein synthesis (e.g., the dolichols), steroid hormone signaling (e.g., androgens, estrogens, and cortisol), and mitochondrial health (e.g., coenzyme Q). Human isoprenoids derive from the mevalonic acid (MVA) pathway, whereas many other organisms utilize the methyl erythritol phosphate (MEP) pathway.

Chemistry and thermodynamics of f-block materials: from nuclear fuels to waste forms

Abstract: New types of fuel materials and ceramics are needed to be studied for the emerging and next generation nuclear reactor technology development. Their development requires our fundamental understanding and accurate description of structures, thermochemical stability, mechanical performance, and phase equilibria. In our group, we use a suite of structural-thermodynamic techniques to achieve this understanding.

Molecular Engineering of Recognition Motifs for Responsive Biomaterials

Abstract: Nature abounds with elegant structures and functions, often governed by equilibrium-based recognition motifs. These natural systems inspire the development of synthetic analogues with diverse functions, including applications in biomaterials and drug delivery. The nanoarchitecture of biological materials arises from precisely engineered molecular-scale interactions and active modulation of thermodynamic parameters, which shape the free energy landscape governing material formation.

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