Abstract: The selective generation and controlled reactivity of open-shell reactive species continues to serve as inspiration for new reaction development in chemical synthesis. This talk will describe recent advances using phosphorous-based reagents to generate carbon- and heteroatom-centered radicals via sequential atom-transfer radical additions as well as the use of copper compounds engaged in light-mediated metal-ligand co-operativity to harness and activate non-conjugated alkenes towards photocycloadditions. Efforts in methods development will be presented alongside mechanistic investigations through a combination of experimental spectroscopies and computational studies.

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