Abstract: Our lab uses different methods for the discovery of the molecular mechanisms by which different RNA viruses subvert human cells in order to discover strategies to block virus propagation. These include bioorthogonal chemistry, small molecule probes, activity-based protein profiling, and genetic code expansion techniques. The presentation will include examples from recent studies that illustrate how new methods can be used to uncover the molecular details driving virus-host interactions to facilitate the discovery of biological mechanisms and potential targets for therapeutic intervention.