Abstract:

This dissertation unveils innovative approaches to designing and constructing NMR circuits, paving the way for advanced nuclear magnetic resonance (NMR) technologies. By employing two distinct circuit-building strategies—lumped element and distributed element (transmission line) designs—I demonstrate how to craft resonating circuits tailored to nuclei such as ¹H, ²H, ¹³C, and ¹⁵N. These circuits unlock the potential for multidimensional NMR experiments, offering deeper insights into molecular structures. Beyond circuit design, this work introduces automation to streamline NMR probe development. A standout tool, the Auto-Ball Shift (ABS), revolutionizes testing by mapping radiofrequency (rf) field homogeneity in both existing and cutting-edge transceiver coil designs. This user-friendly, hands-free benchtop assay saves time and includes a “probe-in-a-box” feature, simulating NMR probe circuits to evaluate critical rf properties. Additionally, I harness additive manufacturing (3D printing) to transform traditionally machined NMR probe components, leveraging new commercial 3D printing techniques for custom, purpose-built parts. The culmination of this research is a fully 3D-printed NMR probe, showcasing its construction. This thesis bridges engineering and science, delivering practical tools and fresh perspectives for NMR innovation.