THE NOWICK RESEARCH GROUP

Selected Publications

α-Methylation Enables the X-ray Crystallographic Observation of Oligomeric Assemblies Formed by a β-Hairpin Peptide

Samdin, T. D.; Kreutzer, A. G.; Sahrai, V.; Wierzbicki, M.; Nowick, J. S.

J. Org. Chem. 2024, XXXX, XXX, XXX-XXX. pdf html SI

 

PDB: 9BI3

Teixobactin "Swapmers" With L Tail Stereochemistry Retain Antibiotic Activity

Griffin, J. H.; Mendoza, A.-T.; Nowick, J. S.

J. Org. Chem. 2024, 89, 20, 15325-15330. pdf html SI

 

Structure-Activity Relationship Studies of the Peptide Antibiotic Clovibactin

Brunicardi, J. E. H.; Griffin, J. H.; Ferracane, M. J.; Kreutzer, A. G.; Small, J.; Mendoza, A.-T.; Ziller, J. W.; Nowick, J. S.

J. Org. Chem. 2024, 89, 17, 12479-12484. pdf html SI

 

PDB: 9BIC

Investigation of Isobactin Analogs of Teixobactin

Jones, C. R.; Lai, G. H.; Padilla, M. S. T. L.; Nowick, J. S.

ACS Med. Chem. Lett. 2024, 15, 1136-1142. pdf html SI

 

A turn for the worse: Aβ-hairpins in Alzheimer's disease

Ruttenberg, S. M.; Nowick, J. S.

Bioorg. Med. Chem. 2024, 105, 117715. pdf html

 

β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides

Ruttenberg, S. M.; Kreutzer, A. G.; Truex, N. L.; Nowick, J. S.

Biochemistry 2024, 63, 212-218. pdf html SI

 

PDB: 8GJD, 8GJC

Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue

Kreutzer, A. G.; Parrocha, C. M. T.; Haerianardakani, S.; Guaglianone, G.; Nguyen, J. T.; Diab, M. N.; Yong, W.; Perez, M.; Head, E.; Nowick, J. S.

ACS Central Science, 2024, 10, 104-121. pdf html SI

 

PDB: 7U4P

A β-Barrel-Like Tetramer Formed by a β-Hairpin Derived from Aβ

Samdin; T. D.; Jones; C. R.; Guaglianone, G.; Kreutzer, A. G.; Freites, J. A.; Wierzbicki, M.; Nowick, J. S.

Chem. Sci. 2024, 15, 285-297 pdf html SI

 

PDB: 7RTZ

Generation and Study of Antibodies against Two Triangular Trimers Derived from Aβ

Kreutzer, A. G.†; Malonis, R. J.†; Parrocha, C. M. T.; Tong, K.; Guaglianone, G.; Nguyen, J. T.; Diab, M. N.; Lai, J. R.; Nowick, J. S.

Pept. Sci. 2024, 116 (2), e24333 pdf html SI

 

†A.G.K. and R.J.M. contributed equally to this work.

 

PDB: 8T0O

Supramolecular Interactions of Teixobactin Analogues in the Crystal State

Yang, H.; Kreutzer, A. G.; Nowick, J. S.

J. Org. Chem. 2024, 89 (7), 5104-5108 pdf html SI

 

PDB: 8U78

 

 

Probing Differences among Aβ Oligomers with Two Triangular Trimers Derived from Aβ

Kreutzer, A. G.†; Guaglianone, G.†; Yoo, S.; Parrocha, C. M. T.; Ruttenberg, S. M.; Malonis, R. J.; Tong, K.; Lin, Y.; Nguyen, J. T.; Howitz, W. J.; Diab, M. N.; Hamza, I. L.; Lai, J. R. Wysocki, V. H.; Nowick, J. S.

Proc. Natl. Acad. Sci. U. S. A. 2023, 120, e2219216120 pdf html SI

 

†A.G.K. and G.G. contributed equally to this work.

 

PDB: 8ECA, 8EC9

 

 

Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29

Krumberger, M.†; Li, X.†; Kreutzer, A. G.; Peoples, A.J.; Nitti, A. G.; Cunningham, A. M.; Jones, C. R.; Achorn, C.; Ling, L. L.; Hughes, D. E.; Nowick, J. S.

J. Org. Chem. 2023, 88, 2214-2220 pdf html SI

 

†M.K. and X. L. contributed equally to this work.

 

 

 

 

Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives

Jones, C. R.; Guaglianone, G.; Lai, G. H.; Nowick, J. S.

Chem. Sci. 2022, 13, 13110-13116 pdf html SI

 

 

 

 

 

 

Teixobactin Kills Bacteria by a Two-pronged Attack on the Cell Envelope

Shukla, R.; Lavore, F.; Maity, S. Derks, M. G. N.; Jones, C. R.; Vermeulen, B. J. A.; Melcrova, A.; Morris, M. A.; Becker, L. M. Wang, X.; Kumar, R.; Medeiros-Silva, J.; van Beekveld, R. A. M.; Bonvin, A. M. J. J.; Lorent, J. H.; Lelli, M.; Nowick, J. S.; MacGillavry, H. D.; Peoples, A. J.; Spoering, A. L.; Ling, L. L.; Hughes, D. E.; Roos, W. H.; Breukink, E.; Lewis, K.; Weingarth, M.

Nature 2022, 608, 390-396 pdf html SI

 

 

 

 

 

 

Elucidating the Oligomerization and Cellular Interactions of a Trimer Derived from Aβ through Fluorescence and Mass Spectrometric Studies

Guaglianone, G.; Torrado, B.; Lin, Y.; Watkins, M. C.; Wysocki, V. H.; Gratton, E.; Nowick, J. S.

ACS Chem. Neurosci. 2022, 13, 2473-2482 pdf html SI

 

 

 

 

 

 

Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease

Parrocha, C. M. T.; Nowick, J. S.

Pept. Sci. 2022, e24289 pdf html

 

 

 

 

 

 

Enantiomeric β-Sheet Peptides from Aβ Form Homochiral Pleated β-Sheets Rather Than Heterochiral Rippled β-Sheets

Li, X.; Rios, S. E.; Nowick, J. S.

Chem. Sci. 2022, 13, 7739-7746 pdf html SI Cover Art

 

 

 

 

 

 

 

 

Visualizing the Mode of Action and Supramolecular Assembly of Teixobactin Analogues in Bacillus subtilis

Morris, M, A,; Vallmitjana, A.; Grein, F.; Schneider, T.; Arts, M.; Jones, C. R.; Nguyen, B. T.; Hashemian, M. H.; Malek, M.; Gratton, E.;

Nowick, J. S.

Chem. Sci. 2022, 13, 7747-7754. pdf html SI Cover Art

 

 

 

 

 

 

Effects of Familial Alzheimer’s Disease Mutations on the Assembly of a β-Hairpin Peptide Derived from Aβ16–36

McKnelly, K. J.; Kreutzer, A. G.; Howitz, W. J.; Haduong, K.; Yoo, S.; Hart, S.; Nowick, J. S.

Biochemistry 2022, 61, 446-454 pdf html SI

 

 

 

 

 

 

Macrocyclic Peptides Derived from Familial Alzheimer’s Disease Mutants Show Charge-Dependent Oligomeric Assembly and Toxicity

Howitz, W. J.; Guaglianone, G.; McKnelly, K. J.; Haduong, K.; Ashby, S. N.; Laayouni, M.; Nowick, J. S.

ACS Chem. Neurosci. 2022, 13, 714-720 pdf html SI

 

 

 

 

 

 

A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils

Zhang, S.; Yoo, S.; Snyder, D. T.; Katz, B. B.; Henrickson, A.; Demeler, B.; Wysocki, V. H.; Kreutzer, A. G. Nowick, J. S.

Biochemistry 2022, 61, 4, 252-264 pdf html SI

 

 

 

 

 

 

Synthesis and Application of Fluorescent Teixobactin Analogs

Morris, M. A.; Jones, C. R.;  Nowick, J. S.

Meth. Enzymol. 2022, 665, 233-258 pdf html

 

 

 

 

 

 

Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM

Hurst, P. J.; Morris, M. A.; Graham, A. A.; Nowick, J. S.; Patterson, J. P.

ACS Omega 2021, 6, 27412-27417 pdf html SI

 

 

 

 

 

 

An Improved Turn Structure for Inducing β-Hairpin Formation in Peptides

Li, X.; Sabol, A. L.; Wierzbicki, M.; Salveson, P. J.;  Nowick, J. S.

Angew. Chem. Int. Ed. 2021, 60, 22776-22782 pdf html SI

 

 

 

 

 

 

Exploring Amyloid Oligomers with Peptide Model Systems

Samdin, T. D.; Kreutzer, A. G.; Nowick, J. S.

Curr. Opin. Chem. Biol. 2021, 64, 106-115 pdf html

 

 

 

 

 

 

Synthesis and Study of Macrocyclic β-Hairpin Peptides for Investigating Amyloid Oligomers

Guaglianone, G.; Kreutzer, A. G.; Nowick, J. S.

Meth. Enzymol. 2021, 656, 123-168. pdf html

 

 

 

 

 

 

A Cyclic Peptide Inhibitor of the SARS-CoV-2 Main Protease

Kreutzer, A. G.; Krumberger, M.; Diessner, E. M.; Parrocha, C. M. T.; Morris, M. A.; Guaglianone, G.; Butts, C. T.; Nowick, J. S.

Eur. J. Med. Chem. 2021, 221, 113530 pdf html SI

 

 

 

 

 

 

PREPRINT: Kreutzer, A. G.; Krumberger, M.; Parrocha, C. M. T.; Morris, M. A.; Guaglianone, G.; Nowick, J. S.

bioRxiv doi: https://doi.org/10.1101/2020.08.03.234872

An aza-Diels–Alder Route to Quinoline-Based Unnatural Amino Acids and Polypeptide Surrogates

Umerani, M. J.; Yang, H.; Pratakshya, P.; Nowick, J. S.; Gorodetsky, A. A.

RSC Adv. 2021, 11, 14132-14139 pdf html SI

 

 

 

Expression of N-Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42

Zhang, S.; Guaglianone, G.; Morris, M. A.; Yoo, S.; Howitz, W. J.; Xing, L.; Zheng, J.; Jusuf, H.; Huizar, G.; Lin, J.; Kreutzer, A. G.; Nowick, J. S.

Biochemistry 2021, 60, 1191-1200 pdf html SI Correction: Biochemistry 2021 pdf html

 

 

 

Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientists

Zhang, S.; Krumberger, M.†; Morris, M. A.†; Parrocha, C. M. T.; Kreutzer, A. G.; Nowick, J. S.

Eur. J. Med. Chem. 2021, 218, 11390 pdf html SI

 

Tutorial video

 

†M.K. and M. A. M. contributed equally to this work.

 

PREPRINT: Zhang, S.; Krumberger, M.; Morris, M. A.; Parrocha, C. M. T.; Griffin, J. H.;

Kreutzer, A. G.; Nowick J. S. ChemRxiv, doi: https://doi.org/10.26434/chemrxiv.12791954

Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by β-Hairpins Derived from Aβ

Haerianardakani, S.; Kreutzer, A. G.; Salveson, P.; Samdin, T. D.; Guaglianone, G. E.; Nowick, J. S.

J. Am. Chem. Soc. 2020, 142, 20708-20716 pdf html SI

 

PDB: 7JXN, 7JXO

 

Interpreting Cubes in the X-Ray Crystallographic Structure of a Peptide Derived from Medin19–36

Howitz, W. J.; Wierzbicki, M.; Cabanela, R. W.; Saliba, C.; Motovalli, A.; Tran, N.; Nowick, J. S.

J. Am. Chem. Soc. 2020, 142, 15870-15875 pdf html SI

 

PDB: 7JRH

 

X-Ray Crystallography Reveals Parallel and Antiparallel β-Sheet Dimers of a β-Hairpin Derived from Aβ16–36 that Assemble to Form Different Tetramers

Kreutzer, A. G.; Samdin, T. D.; Guaglianone, G.; Spencer, R. K.; Nowick, J. S.

ACS Chem. Neurosci. 2020, 11, 2340-2347 pdf html SI

 

PDB: 6WXM

 

Effects of N-Terminal Residues on the Assembly of Constrained β-Hairpin Peptides Derived from Aβ

Samdin, T. D.; Wierzbicki, M.; Kreutzer, A. G.; Howitz, W. J.; Valenzuela, M.; Smith, A.; Sahrai, V. S.; Truex, N. L.; Klun, M.; Nowick, J. S.

J. Am. Chem. Soc. 2020, 142, 11593-11601. pdf html SI

 

PDB: 6VU4

A Fluorescent Teixobactin Analogue

Morris, M. A.; Malek, M.; Hashemian, M. H.; Nguyen, B. T.; Manuse S.; Lewis, K.; Nowick, J. S.

ACS Chem. Biol. 2020, 15, 1222-1231. pdf html SI

This article is part of the Chemical Microbiology special issue.

Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, & HCTU

McKnelly, K. J.; Sokol, W.; Nowick, J. S.

J. Org. Chem. 2020, 85, 1764-1768. pdf html SI

 

 

 

 

Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin

Yang, H; Pishenko, A. V.; Li, X.; Nowick, J. S.

J. Org. Chem. 2020, 85, 1331-1339. pdf html SI

 

PDB: 6PSL

 

 

Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers

Sahoo, B. R.; Bekier, M. E., II; Liu, Z.; Kocman, V.; Stoddard, A. K.; Anantharamaiah, G. M.; Nowick, J.; Fierke, C.; Wang, Y.; Ramamoorthy, A.

J. Mol. Biol. 2020, 432, 1020-1034. html

Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation

Lu, J.; Cao, Q.; Wang, C.; Zheng, J.: Luo, F.; Xie, J.; Li, Y.; Ma, X.; He, L.; Eisenberg, D.; Nowick, J.; Jiang, L.; Li, D.

Front. Mol. Neurosci. 2019, 12, 54. html

X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly

Yang, H; Wierzbicki, M.; Du Bois, D. R.; Nowick, J. S.

J. Am. Chem. Soc. 2018, 140, 14028-14032. pdf html SI

 

PDB: 6E00

 

Repurposing triphenylmethane dyes to bind to trimers derived from Aβ

Salveson, P. J.; Haerianardakani, S.; Thuy-Boun, A.; Yoo, S.; Kreutzer, A. G.; Nowick, J. S.

J. Am. Chem. Soc. 2018, 140, 11745-11754. Correction: J. Am. Chem. Soc. 2018, 140, 15546-15546. pdf html SI

 

PDB: 6DR4 6DR5 6DR6

 

 

An efficient method for the expression and purification of Aβ(M1–42)

Yoo, S.†; Zhang, S.†; Kreutzer, A. G.; Nowick, J. S.

Biochemistry 2018, 57, 3861-3866. pdf html SI

 

†S. Y. and S. Z. contributed equally to this work.

 

 

 

Controlling the Oligomerization State of Aβ-derived Peptides with Light

Salveson, P. J.; Haerianardakani, S.; Thuy-Boun, A.; Kreutzer, A. G.; Nowick, J. S.

J. Am. Chem. Soc. 2018, 140, 5842-5852. pdf html SI

 

PDB: 6CG3 6CG4 6CG5

 

 

Effects of Charge and Hydrophobicity on the Oligomerization of Peptides Derived from IAPP

Wang, Y.; Truex, N. L.; Vo, N. D. P.; Nowick, J. S.

Bioorganic Med. Chem. 2018, 26, 1151-1156. pdf html SI

 

 

Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species

Buchanan, l. E.; Maj, M.; Dunkelberger, E. B.; Cheng, P.-N.; Nowick, J. S.; Zanni, M. T.

Biochemistry 2018, 57, 6470–6478. pdf html SI

A Hexamer of a Peptide Derived from Aβ 16–36

Kreutzer, A. G.; Spencer, R. K.; McKnelly, K. J.; Yoo, S.; Hamza, I. L.; Salveson, P. J.; Nowick, J. S.

Biochemistry 2017, 56, 6061-6071. pdf html SI

 

PDB: 5W4H 5W4I 5W4J

Alanine Scan Reveals Modifiable Residues in Teixobactin

Chen, K.H.; Le, S. P.; Han, X.; Frias, J. M.; Nowick, J. S.

Chem. Commun. 2017, 53, 11357-11359. pdf html SI

 

 

Transmembrane Proteins: Amyloids Hidden in Plain Sight?

Truex, N. L.; Nowick, J. S.

Biochemistry 2017, 56, 4735-4736. pdf html

 

A Tetramer Derived from Islet Amyloid Polypeptide

Wang, Y.; Kreutzer, A. G.; Truex, N.L.; Nowick, J. S.

J. Org. Chem. 2017, 82, 7905-7912. pdf html SI

 

PDB: 5UHR

 

X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16–36

Salveson, P. J†.; Spencer, R. K.†; Kreutzer, A. G.†; Nowick, J. S.

Org. Lett. 2017, 19, 3462-3465. pdf html SI

 

PDB: 5V63 5V64 5V65

 

†P. J. S., R. K. S., and A. G. K. contributed equally to this work.

 

X-ray Crystallographic Structure of a Giant Double-Walled Peptide Nanotube Formed by a Macrocyclic β-Sheet Containing Aβ16–22

Chen, K. H.; Corro, K. A.; Le, S. P.; Nowick, J. S.

J. Am. Chem. Soc. 2017, 139, 8102-8105. pdf html SI

 

PDB: 5VF1

 

X-ray Crystallographic Structure of a Teixobactin Analogue Reveals Key Interactions of the Teixobactin Pharmacophore

Yang, H.; Du Bois, D. R.; Ziller, J. W.; Nowick, J. S.

Chem. Commun. 2017, 53, 2772-2775. pdf html SI cif

 

 

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ

Kreutzer, A. G.; Yoo, S.; Spencer, R. K.; Nowick, J. S.

J. Am. Chem. Soc. 2017, 139, 966-975. pdf html SI

 

PDB: 5SUR 5SUS 5SUT 5SUU

 

Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid

Truex, N. L.; Wang, Y.; Nowick, J. S.

J. Am. Chem. Soc. 2016, 138, 13882-13890. pdf html SI

 

Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid

Truex, N. L.; Nowick, J. S.

J. Am. Chem. Soc. 2016, 138, 13891-13900. pdf html SI

 

Square channels formed by a peptide derived from transthyretin

Yoo, S.; Kreutzer A. G.; Truex, N. L.; Nowick, J. S.

Chem. Sci. 2016, 7, 6946-6951. pdf html SI

 

PDB: 5HPP

Elucidation of the Teixobactin Pharmacophore

Yang, H.; Chen, K. H.; Nowick, J. S.

ACS Chem. Biol. 2016, 11, 1823-1826. pdf html SI

X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17-36 β-Hairpin

Kreutzer, A. G.; Hamza, I. L.; Spencer, R. K.; Nowick, J. S.

J. Am. Chem. Soc. 2016, 138, 4634-4642. pdf html SI

 

PDB: 5HOW 5HOX 5HOY

Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins

Morse, R. P.; Willett, J. L. E.; Johnson, P. M.; Zheng, J.; Credali, A.; Iniguez, A.; Nowick, J. S.; Hayes, C. S.; Goulding. C. W.

J. Mol. Biol. 2015, 427, 3766-3784. pdf html SI

 

PDB: 4ZQU 4ZQV 4ZQW

X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin

Spencer, R. K.; Kreutzer, A. G.; Salveson, P. J.; Li, H.; Nowick, J. S.

J. Am. Chem. Soc. 2015, 137, 6304-6311. pdf html SI

 

PDB: 4P4V 4P4W 4P4X 4P4Y 4P4Z 4WC8 4X0S

A Newcomer’s Guide to Peptide Crystallography

Spencer, R. K.; Nowick, J. S.

Israel J. Chem. 2015, 55, 698-710. pdf html

 

A Fibril-like Assembly of Oligomers of a Peptide Derived from β-Amyloid

Pham, J. D.; Spencer, R. K.; Chen, K. H.; Nowick, J. S.

J. Am. Chem. Soc. 2014, 136, 12682-12690. pdf html SI

 

PDB: 4Q8D

Polymorphism of Oligomers of a Peptide from β-Amyloid

Pham, J. D.; Demeler, B.; Nowick, J. S.

J. Am. Chem. Soc. 2014, 136, 5432–5442. pdf html SI

Mechanism of IAPP Amyloid Fibril Formation Involves an Intermediate with a Transient β-Sheet

Buchanan, L. E.; Dunkelberger, E. B.; Tran, H. Q.; Cheng, P.-N.; Chiu, C.-C.; Cao, P.; Raleigh, D. P.; de Pablo, J. J.; Nowick, J. S.; Zanni, M. T.

Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 19285-19290. pdf html SI

Structures of Oligomers of a Peptide from β-Amyloid

Pham, J. D.; Chim, N.; Goulding, C. W.; Nowick, J. S.

J. Am. Chem. Soc. 2013, 135, 12460-12467. pdf html SI

 

PDB: 4IVH

Recipe for β-Sheets: Foldamers Containing Amyloidogenic Peptide Sequences

Spencer, R.; Chen, K. H.; Manuel, G.; Nowick, J. S.

Eur. J. Org. Chem. 2013, 3523-3528. pdf html SI

A Hydrophobic Surface is Essential to Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

Zheng, J.; Baghkhanian, A. M.; Nowick, J. S.

J. Am. Chem. Soc. 2013, 135, 6846-6852. pdf html SI

The Supramolecular Chemistry of β-Sheets

Cheng, P.-N.; Pham, J. D.; Nowick, J. S.

J. Am. Chem. Soc. 2013, 135, 5477–5492. pdf html

 

Amyloid β-Sheet Mimics that Antagonize Protein Aggregation and Reduce Amyloid Toxicity

Cheng, P.-N.; Liu, C.; Zhao, M.; Eisenberg, D.; Nowick, J. S.

Nat. Chem. 2012, 4, 927-933. pdf html SI

 

PDB: 3T4G

Out-of-Register β-Sheets Suggest a Pathway to Toxic Amyloid Aggregates

Liu, C.; Zhao, M.; Jiang, L.; Cheng,P.-N.; Park, J.; Sawaya M.R.; Pensalfini, A.; Gou, D.; Berk A. J.; Glabe C. G.; Nowick, J. S.; Eisenberg. D.

Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 20913-20918. pdf html SI

 

PDB: 4E0K 4E0L 4E0M 4E0N 4E0O

Heterodivalent Linked Macrocyclic β-Sheets with Enhanced Activity against Aβ Aggregation: Two Sites are Better than One

Cheng, P.-N.; Spencer, R.; Woods, R. J.; Glabe, C. G.; Nowick, J. S.

J. Am. Chem. Soc. 2012, 133, 14179-14184. pdf html SI

Litter decay rates are determined by lignin chemistry

Talbot, J. M.; Yelle, D. J.; Nowick, J. S.; Treseder, K. K.

Biogeochemistry 2012, 108, 279-295. html

Giant Macrolactams Based on β-Sheet Peptides

Cheng,P.-N.; Nowick, J. S.

J. Org. Chem. 2011, 76, 3166-3173. pdf html SI

Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics

Liu, C.; Sawaya, M. R.; Cheng, P.-N.; Zheng, J.; Nowick, J. S.; Eisenberg, D.

J. Am. Chem. Soc. 2011, 133, 6736-6744. pdf html SI

 

PDB: 3Q9G 3Q9H 3Q9I 3Q9J

Macrocyclic β-Sheet Peptides that Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

Zheng, J.; Liu, C.; Sawaya, M. R.; Vadla, B.; Khan, S.; Woods, R. J.; Eisenberg, D.; Goux, W. J.; Nowick, J. S.

J. Am. Chem. Soc. 2011, 133, 3144-3157. pdf html SI

Nanometer-Scale Water-Soluble Macrocycles from Nanometer-Sized Amino Acids

Gothard, C. M.; Nowick, J. S.

J. Org. Chem. 2010, 75, 1822-1830. pdf html SI

In Memoriam: Arthur Stanley Nowick

Nowick, J. S.; Nowick, S. M.

MRS Bulletin 2010, 35, 736-737.

X-ray Crystallographic Structure of an Artificial β-Sheet Dimer

Khakshoor, O.; Lin, A. J.; Korman, T. P.; Sawaya, M. R.; Tsai, S.-C.; Eisenberg, D.; Nowick, J. S.

J. Am. Chem. Soc. 2010, 132, 11622-11628. pdf html SI

 

PDB: 3NI3

Use of Disulfide "Staples" To Stabilize β-Sheet Quaternary Structure

Khakshoor, O.; Nowick, J. S.

Org. Lett. 2009, 11, 3000-3003. pdf html SI

A New Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions

Levin, S.; Nowick, J. S.

Org. Lett. 2009, 11, 1003-1006. pdf html SI

Functionalized Analogues of an Unnatural Amino Acid that Mimics a Tripeptide β-Strand

Khasanova, T. V.; Khakshoor, O.; Nowick, J. S.

Org. Lett. 2008, 10, 5293-5296. pdf html SI

Artificial β-Sheets: Chemical Models of β-Sheets

Khakshoor, O.; Nowick, J. S.

Curr. Opin. Chem. Biol. 2008, 12, 722-729. pdf html

Exploring β-Sheet Structure and Interactions with Chemical Model Systems

Nowick, J. S.

Acc. Chem. Res. 2008, 41, 1319-1330. pdf html

 

An Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions

Levin, S.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 13043-13048. pdf html SI

Nanometer-Sized Amino Acids for the Synthesis of Nanometer-Scale Water-Soluble Molecular Rods of Precise Length

Gothard, C. M.; Rao, N. A.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 7272-7273. pdf html SI

Macrocyclic β-Sheet Peptides that Mimic Protein Quaternary Structure through Intermolecular β-Sheet Interactions

Khakshoor, O.; Demeler, B.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 5558-5569. pdf html SI

Cyclic Modular β-Sheets

Woods, R. J.; Brower, J. O.; Castellanos, E.; Hashemzadeh, M.; Khakshoor, O.; Russu, W. A.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 2548-2558. pdf html SI

A New Class of Macrocyclic Receptors from iota-Peptides

Kang, S.-W. Gothard, C. M.; Maitra, S.; Atia-tul-Wahab; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 1486-1487. pdf html SI

 

The Absence of Favorable Aromatic Interactions between β-Sheet Peptides

Chung, D. M.; Dou, Y.; Baldi, P.; Nowick, J. S.

J. Am. Chem. Soc. 2005, 127, 9998-9999. pdf html

Enantioselective Molecular Recognition between β-Sheets

Chung, D. M.; Nowick, J. S.

J. Am. Chem. Soc. 2004, 126, 3062-3063. pdf html SI

ICBS: A Database of Protein-Protein Interactions Mediated by β-Sheet Formation

Dou, Y.; Baisnée, P.-F.; Pollastri, G.; Pécout, Y.; Nowick, J.; Baldi, P.

Bioinformatics 2004, 20, 2767-2777. pdf

 

DSA: A New Internal Standard for NMR Studies in Aqueous Solution

Nowick, J. S.; Khakshoor, O.; Hashemzadeh, M.; Brower, J. O.

Org. Lett. 2003, 5, 3511-3513. pdf html SI

 

Dityrosine Crosslinked Aβ Peptides: Fibrillar Beta Structure in Aβ(1-40) is Conducive to Formation of Dityrosine Crosslinks, but a Dityrosine Crosslink in Aβ(8-14) does not Induce Beta Structure

Yoburn, J. C.; Tian, W. Q.; Brower, J. O.; Nowick, J. S.; Glabe, C. G.; Van Vranken, D. L.

Chem. Res. Toxicol. 2003, 16, 531-535. pdf html

 

 

Sequence-Selective Molecular Recognition Between β-Sheets

Nowick, J. S.; Chung, D. M.

Angew. Chem., Int. Ed. 2003, 42, 1765-1768. pdf html

 

A New Turn Structure for the Formation of β-Hairpins in Peptides

Nowick, J. S.; Brower, J. O.

J. Am. Chem. Soc. 2003, 125, 876-877. pdf html

 

A Ribozyme with Michaelase Activity: Synthesis of the Substrate Precursors

Eisenführ, A.; Arora, P. S.; Sengle, G.; Takaoka, L. R.; Nowick J. S.; Famulok, M.

Bioorg. Med. Chem. 2003, 11, 235-249. pdf html

Methylglyoxal Synthetase, enol-Pyruvaldehde, Glutathione, and the Glyoxalase System

Rose, I. A.; Nowick, J. S.

J. Am. Chem. Soc. 2002, 124, 13047-13052. pdf html

 

An Unnatural Amino Acid that Induces β-Sheet Folding and Interaction in Peptides

Nowick, J. S.; Lam, K. S.; Khasanova, T. V.; Kemnitzer, W. E.; Maitra, S.; Mee, H. T.; Liu, R.

J. Am. Chem. Soc. 2002, 124, 4972-4973. pdf html SI

 

Three-Stranded Mixed Artificial β-Sheets

Nowick, J. S.; Smith, E. M.; Ziller, J. W.; Shaka, A. J.

Tetrahedron 2002, 58, 727-739. html

Starving at the Banquet

Nowick, J. S.

Chem Eng. News 2001, 79(13), 178. pdf

A Triply Templated Artificial β-Sheet

Nowick, J. S.; Cary, J. M.; Tsai, J. H.

J. Am. Chem. Soc. 2001, 123, 5176-5180. pdf html SI

Novel RNA Catalysts for the Michael Reaction

Sengle, G.; Eisenführ, A.; Arora, P. S.; Nowick, J. S.; Famulok, M.

Chemistry & Biology 2001, 8, 459-473. html

An Unnatural Amino Acid that Mimics a Tripeptide β-Strand and Forms β-Sheetlike Hydrogen-Bonded Dimers

Nowick, J. S.; Chung, D. M.; Maitra, K.; Maitra, S.; Stigers, K. D.; Sun, Y.

J. Am. Chem. Soc. 2000, 122, 7654-7661. pdf html

Fmoc*: A More Soluble Analogue of the 9-Fluorenylmethoxycarbonyl Protecting Group

Stigers, K. D.; Koutroulis, M. R.; Chung, D. M.; Nowick, J. S.

J. Org. Chem. 2000, 65, 3858-3860. pdf html

"Synthesis, Incorporation Efficiency, and Stability of Disulfide Bridged Functional Groups at RNA 5'-Ends" Sengle, G.; Jenne, A.; Arora, P. S.; Selig, B.; Nowick, J. S.; Jäschke, A.; Famulok, M. Bioorg. Med. Chem. 2000, 8, 1317-1329. pdf html

 

"Synthesis of Amino Acid Ester Isocyanates: Methyl (S)-2-Isocyanato-3-phenylpropanoate" Tsai, J. H.; Takaoka, L. R.; Powell, N. A.; Nowick, J. S.  Org. Synth. 2000, 78, 220-224. pdf html

 

"Designed Molecules that Fold to Mimic Protein Secondary Structures" Stigers, K. D.; Soth, M. J.; Nowick, J. S. Curr. Opin. Chem. Biol. 1999, 3, 714-723. pdf html

 

"A Chemical Model of a Protein β-Sheet Dimer" Nowick, J. S.; Tsai, J. H.; Bui, Q.-C. D.; Maitra, S. J. Am. Chem. Soc. 1999, 121, 8409-8410.

pdf html SI

 

"Folding of an Artificial β-Sheet in Competitive Solvents" Junquera, E.; Nowick, J. S. J. Org. Chem. 1999, 64, 2527-2531. pdf html SI

 

"Two New β-Strand Mimics" Tsai, J. H.; Waldman, A. S.; Nowick, J. S.  Bioorg. Med. Chem. 1999, 7, 29-38. pdf html

 

"A Peptide/Oligourea/Azapeptide Hybrid That Adopts a Hairpin Turn"  Soth, M. J.; Nowick, J. S.  J. Org. Chem. 1999, 64, 276-281.

pdf html SI

 

"Chemical Models of Protein β-Sheets" Nowick, J. S.  Acc. Chem. Res. 1999, 32, 287-296. pdf html

 

"An Efficient Synthesis of N,N'-Linked Oligoureas"  Wilson, M. E.; Nowick, J. S. Tetrahedron Lett. 1998, 39, 6613-6616. html

 

"Design and Synthesis of a Transition State Analog for the Diels-Alder Reaction" Arora, P. S; Van, Q. N.; Famulok, M.; Shaka, A. J.; Nowick, J. S.  Bioorg. Med. Chem. 1998, 6, 1421-1428. pdf html

 

"The Alginate Demonstration:  Polymers, Food Science, and Ion Exchange"  Waldman, A. S.; Schechinger, L.; Govindarajoo, G.; Nowick, J. S.; Pignolet, L. H.  J. Chem. Educ. 1998, 75, 1430-1431. pdf html

 

"An Artificial Antiparallel β-Sheet Containing a New Peptidomimetic Template" Smith, E. M.; Holmes, D. L.; Shaka, A. J.; Nowick, J. S.  J. Org. Chem. 1997, 62, 7906-7907. pdf html SI

 

"The Propensities of Amino Acids to Form Parallel β-Sheets" Nowick, J. S.; Insaf, S.  J. Am. Chem. Soc. 1997, 119, 10903-10908. pdf html SI

 

"Model Behaviour"  Nowick, J. S. Chem. Br. 1997, 33(12), 36-39.

 

"Unnatural Oligomers and Oligomer Libraries" Soth, M. J.; Nowick, J. S.  Current Opinion in Chemical Biology 1997, 1, 120-129. html

 

"Solid-Phase Synthesis of Artificial β-Sheets" Holmes, D. L.; Smith, E. M.; Nowick, J. S.  J. Am. Chem. Soc. 1997, 119, 7665-7669.

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"An Extended β-Strand Mimic for a Larger Artificial β-Sheet" Nowick, J. S.; Pairish, M.; Lee, I. Q.; Holmes, D. L.; Ziller, J. W. J. Am. Chem. Soc. 1997, 119, 5413-5424. pdf html SI

 

"Artificial β-Sheets"  Nowick, J. S.; Smith, E. M.; Pairish, M. Chem. Soc. Rev. 1996, 25, 401-415. pdf html

 

"Synthesis of Peptide Isocyanates and Isothiocyanates" Nowick, J. S.; Holmes, D. L.; Noronha, G.; Smith, E. M.; Nguyen, T. M.; Huang, S.-L. J. Org. Chem. 1996, 61, 3929-3934. Addition: J. Org. Chem. 1998, 63, 9144. pdf html

 

"An Artificial β-Sheet Comprising a Molecular Scaffold, a β-Strand Mimic, and a Peptide Strand" Nowick, J. S.; Holmes, D. L.; Mackin, G.; Noronha, G.; Shaka, A. J.; Smith, E. M. J. Am. Chem. Soc. 1996, 118, 2764-2765. pdf html

 

"Triurea Derivatives of Diethylenetriamine as Potential Templates for the Formation of Artificial β-Sheets"  Nowick, J. S.; Mahrus, S.; Smith, E. M.; Ziller, J. W.  J. Am. Chem. Soc. 1996, 118, 1066-1072. pdf html SI

 

"A Coordinated Chemistry Outreach Program that Reaches Thousands of High School Students"  Waldman, A. S.; Schechinger, L.; Nowick, J. S.  J. Chem. Educ. 1996, 73, 762-764. pdf

 

"Molecular Scaffolds 3.  An Artificial Parallel β-Sheet" Nowick, J. S.; Smith, E. M.; Noronha, G.  J. Org. Chem. 1995, 60, 7386-7387.

pdf SI

 

"A Novel Hydrogen-Bonded Dimer Containing a Sixteen-Membered Ring"  Nowick, J. S.; Antonovich, V.; Noronha, G.; Ziller, J. W.  J. Org. Chem. 1995, 60, 1888. pdf

 

"Molecular Scaffolds. 2.  Intramolecular Hydrogen Bonding in 1,2-Diaminoethane Diureas"  Nowick, J. S.; Abdi, M.; Bellamo, K. A.; Love, J. A.; Martinez, E. J.; Noronha, G.; Smith, E. M.; Ziller, J. W.  J. Am. Chem. Soc. 1995, 117, 89-99. pdf SI

 

"Molecular Recognition Between Uncharged Molecules in Aqueous Micelles" Nowick, J. S.; Cao, T.; Noronha, G.  J. Am. Chem. Soc. 1994, 116, 3285-3289. pdf

 

"Molecular Recognition in Micelles:  The Roles of Hydrogen Bonding and Hydrophobicity in Adenine-Thymine Base-Pairing in SDS Micelles" Nowick, J. S.; Chen, J. S.; Noronha, G. J. Am. Chem. Soc. 1993, 115, 7636-7644. pdf

 

"An Improved Method for the Synthesis of Enantiomerically Pure Amino Acid Ester Isocyanates" Nowick, J. S.; Powell, N. A.; Nguyen, T. M.; Noronha, G. J. Org. Chem. 1992, 57, 7364-7366. pdf

 

"Molecular Scaffolds I.  Intramolecular Hydrogen Bonding in a Family of Di- and Triureas" Nowick, J. S.; Powell, N. A.; Martinez, E. J.; Smith, E. M.; Noronha, G. J. Org. Chem. 1992, 57, 3763-3765. pdf SI

 

"Molecular Recognition in Aqueous Micellar Solution:  Adenine-Thymine Base-Pairing in SDS Micelles"  Nowick, J. S.; Chen, J. S.  J. Am. Chem. Soc. 1992, 114, 1107-1108. pdf

Publications Prior to UCI

"Self-Replicating Systems" Famulok, M.; Nowick, J. S.; Rebek, J, Jr.  Acta Chem. Scand. 1992, 46, 315. pdf

 

"Kinetic Studies and Modeling of a Self-Replicating System" Nowick, J. S.; Feng,  Q.; Tjivikua, T.; Ballester, P.; J. Rebek, J., Jr.  J. Am. Chem. Soc. 1991, 113, 8831. pdf

 

"A Practical and Efficient Method for the Synthesis of β-Lactones" Danheiser, R. L.; Nowick, J. S.  J. Org. Chem. 1991, 56, 1176. pdf

 

"Convergent Functional Groups. 9. Complexation in New Molecular Clefts" Nowick, J. S.; Ballester, P.; Ebmeyer, F.; Rebek, J. Jr.  J. Am. Chem. Soc. 1990, 112, 8902. pdf

 

"Application of (α-Phosphonoacyl)silane Reagents to the Synthesis of α,β-Unsaturated Acylsilanes" Nowick, J. S.; Danheiser, R. L.,  J. Org. Chem. 1989, 54, 2798. pdf

 

"The M.I.T. Chemistry Outreach Program: Graduate Students Presenting Chemistry to High School Students" Nowick, J. S.; Brisbois, R. G.  J. Chem. Educ. 1989, 66, 668. pdf

 

"Synthesis of Conjugated Optically Active Polymetallocenes" Katz, T. J.; Sudhakar, A.; Yang, B.; Nowick, J. S.  J. Macromol. Sci., Chem. 1989, A26, 309.

 

"Chemistry of Cyclopropylacylsilanes I.  α-Functionalized Acylsilane Reagents for the Cyclopropanation of Electrophilic Alkenes" Nowick, J. S.; Danheiser, R. L.  Tetrahedron 1988, 44, 4113. pdf html

 

"Application of Chiral Lanthanide-Induced Shift Reagents to Optically Active Cations: The Use of Tris[3-(trifluoromethylhydroxymethylene)-(+)-camphorato]europium(III) to Determine the Enantiomeric Purity of Tris(phenanthroline)ruthenium(II) Dichloride" Barton, J. A.; Nowick, J. S. J. Chem. Soc., Chem. Commun. 1984, 1650. pdf